Symbol
Name
ID

Ighm
immunoglobulin heavy constant mu
MGI:96448

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating antibody level	Agammaglobulinemia	Panhypogammaglobulinemia	Neutropenia	B lymphocytopenia
Disease(s) Associated with IGHM
agammaglobulinemia 1

Mouse Phenotypes

decreased B cell proliferation

increased B cell proliferation

abnormal T cell proliferation

decreased T cell proliferation

abnormal B cell differentiation

abnormal class switch recombination

abnormal immature B cell morphology

decreased immature B cell number

absent immature B cells

decreased transitional stage B cell number

abnormal plasma cell differentiation

increased pro-B cell number

arrested B cell differentiation

decreased dendritic cell number

decreased mature B cell number

absent mature B cells

decreased B-1 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased B-1 B cell number

increased marginal zone B cell number

increased plasma cell number

decreased B cell number

absent B cells

decreased pre-B cell number

increased B cell number

abnormal T cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased osteoclast cell number

abnormal mature B cell morphology

abnormal B-1a B cell morphology

abnormal CD8 positive, alpha-beta intraepithelial T cell morphology

abnormal metallophilic macrophage morphology

abnormal spleen marginal zone macrophage morphology

abnormal spleen morphology

decreased spleen weight

abnormal spleen white pulp morphology

abnormal spleen B cell follicle morphology

decreased spleen B cell follicle number

abnormal spleen germinal center morphology

abnormal spleen marginal sinus morphology

abnormal spleen marginal zone morphology

abnormal spleen periarteriolar lymphoid sheath morphology

abnormal splenic cell ratio

abnormal B cell physiology

abnormal B cell activation

decreased IgA level

increased IgA level

decreased IgE level

decreased IgG1 level

decreased IgG2a level

increased IgG2a level

decreased IgG2b level

decreased IgG3 level

increased IgG3 level

decreased IgG level

decreased IgM level

increased IgM level

decreased immunoglobulin level

abnormal CD4-positive, alpha-beta T cell physiology

Availability

Mouse Genotype

Ighm^{tm1.1(IGH-2)Cog}/Ighm^{tm1.1(IGH-2)Cog}

Ighm^tm1.1Aak/Ighm^tm1.1Aak

Ighm^tm1Cgn/Ighm^tm1Cgn

Ighm^tm1Che/Ighm^tm1Che

Ighm^tm1Msn/Ighm^tm1Msn

Ighm^tm1Sls/Ighm^tm1Sls

Ighm^tm2.1Bgmn/Ighm^tm2.1Bgmn

Ighm^tm3Bgmn/Ighm^tm3Bgmn

Ighm^tm4Bgmn/Ighm^tm4Bgmn

Ighm^tm1Cgn/Ighm⁺

Ighm^tm1Msn/Ighm⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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